In-depth with BC²
Giving donors a look inside the biobank's commitment to transforming samples into impactful cancer research
Publications
Upon completion of a study involving BC² samples, researchers are encouraged to share any of their published findings with the biobank. Provided here is a partial list of these publications, separated based on topic area.
Breast Cancers
• TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer https://pubmed.ncbi.nlm.nih.gov/37057595/ • Evaluation of a Liquid Biopsy-Breast Cancer Methylation (LBx-BCM) Cartridge Assay for Predicting Early Disease Progression and Survival: TBCRC 005 Prospective Trial. https://pubmed.ncbi.nlm.nih.gov/36534524/ • Quantification of spatial pharmacogene expression heterogeneity in breast tumors https://pubmed.ncbi.nlm.nih.gov/35906899/ • Acquisition, processing, and single-cell analysis of normal human breast tissues from a biobank https://pubmed.ncbi.nlm.nih.gov/34977686/ • The Effects of Lifetime Estrogen Exposure on Breast Epigenetic Age https://pubmed.ncbi.nlm.nih.gov/33771849/ • A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells https://pubmed.ncbi.nlm.nih.gov/33763657/ • TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer https://pubmed.ncbi.nlm.nih.gov/31822498/ • Genetic Ancestry-dependent Differences in Breast Cancer-induced Field Defects in the Tumor-adjacent Normal Breast https://pubmed.ncbi.nlm.nih.gov/30718355/
Blood Cancers
• Primary cutaneous peripheral T-cell lymphoma, not otherwise specified with mammalian target of rapamycin mutation: A novel finding for targeted treatment https://pubmed.ncbi.nlm.nih.gov/33304974/
Gastrointestinal Cancers
• LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF-Mutant Colorectal Cancer https://pubmed.ncbi.nlm.nih.gov/34035083/ • ST2 as checkpoint target for colorectal cancer immunotherapy https://pubmed.ncbi.nlm.nih.gov/32376804/ • Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia https://pubmed.ncbi.nlm.nih.gov/33851955/ • Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform https://pubmed.ncbi.nlm.nih.gov/33334063/ • miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2 https://pubmed.ncbi.nlm.nih.gov/31662451/
Lung Cancers
• Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9 https://pubmed.ncbi.nlm.nih.gov/35778404/ • An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment http://pubmed.ncbi.nlm.nih.gov/35179949/
Genitourinary Cancers
• Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer https://pubmed.ncbi.nlm.nih.gov/31413178/ •Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer https://pubmed.ncbi.nlm.nih.gov/35810788/ •RANKL Blockade Reduces Cachexia and Bone Loss Induced by Non-Metastatic Ovarian Cancer in Mice https://pubmed.ncbi.nlm.nih.gov/34904285/ • Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma https://pubmed.ncbi.nlm.nih.gov/33753553/ • Transcriptome Profiling Reveals Matrisome Alteration as a Key Feature of Ovarian Cancer Progression https://pubmed.ncbi.nlm.nih.gov/31600962/ • GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis https://pubmed.ncbi.nlm.nih.gov/36107759/ • Targeting GCN2 Regulation of Amino Acid Homeostasis in Prostate Cancer https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.0R314 • Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer https://pubmed.ncbi.nlm.nih.gov/31840082/
Cancer Detection and Prevention
• Diagnostic Evidence GAuge of Single cells (DEGAS): a flexible deep transfer learning framework for prioritizing cells in relation to disease https://pubmed.ncbi.nlm.nih.gov/35105355/ • Hormonally Regulated Myogenic miR-486 Influences Sex-specific Differences in Cancer-induced Skeletal Muscle Defects https://pubmed.ncbi.nlm.nih.gov/34265069/ • Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone https://pubmed.ncbi.nlm.nih.gov/34230453/ • Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4 https://pubmed.ncbi.nlm.nih.gov/34031366/ • Flower isoforms promote competitive growth in cancer https://pubmed.ncbi.nlm.nih.gov/31341286/ • Thymic Carcinomas and Second Malignancies: A Single-Center Review http://pubmed.ncbi.nlm.nih.gov/34069513/